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The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4
TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathog...
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| Опубликовано в: : | J Leukoc Biol |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Society for Leukocyte Biology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4632169/ https://ncbi.nlm.nih.gov/pubmed/24812060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A0913-487R |
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