The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathog...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Verstak, Brett, Stack, Julianne, Ve, Thomas, Mangan, Matthew, Hjerrild, Kathryn, Jeon, Jannah, Stahl, Rainer, Latz, Eicke, Gay, Nick, Kobe, Bostjan, Bowie, Andrew G., Mansell, Ashley
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2014
Assuntos:
Receptors, Signal Transduction, & Genes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632169/
https://ncbi.nlm.nih.gov/pubmed/24812060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A0913-487R
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