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Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding

Toll-like receptor (TLR)9 performs our innate response to bacterial DNA, warning us of the presence of infection. Inhibitory oligodeoxyribonucleotides (INH-ODN) have been developed that selectively block activation of mouse TLR9. Their inhibitory motif consisting of CCx(not-C)(not-C)xxGGG (x = any b...

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Detalhes bibliográficos
Main Authors: Ashman, Robert F., Goeken, J. Adam, Latz, Eicke, Lenert, Petar
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053407/
https://ncbi.nlm.nih.gov/pubmed/21393636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxq473
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