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Cyclin D Degradation by E3 Ligases in Cancer Progression and Treatment
D cyclins include three isoforms: D1, D2, and D3. D cyclins heterodimerize with cyclin-dependent kinase 4/6 (CDK4/6) to form kinase complexes that can phosphorylate and inactivate Rb. Inactivation of Rb triggers the activation of E2F transcription factors, which in turn regulate expression of genes...
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| Yayımlandı: | Semin Cancer Biol |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7390705/ https://ncbi.nlm.nih.gov/pubmed/32006569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2020.01.012 |
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