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Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/αB-crystallin) ligase and subsequent proteasome-dependent degradation
Protein ubiquitylation is a complex enzymatic process that results in the covalent attachment of ubiquitin, via Gly-76 of ubiquitin, to an ε-NH2-group of an internal lysine residue in a given substrate. While E3 ligases frequently utilize lysines adjacent to the degron within the substrate, many sub...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794935/ https://ncbi.nlm.nih.gov/pubmed/19767775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.287 |
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