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Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/αB-crystallin) ligase and subsequent proteasome-dependent degradation

Protein ubiquitylation is a complex enzymatic process that results in the covalent attachment of ubiquitin, via Gly-76 of ubiquitin, to an ε-NH2-group of an internal lysine residue in a given substrate. While E3 ligases frequently utilize lysines adjacent to the degron within the substrate, many sub...

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Bibliografske podrobnosti
Main Authors: O., Barbash, E., Egan, L.L., Pontano, J., Kosak, Diehl, J. Alan
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794935/
https://ncbi.nlm.nih.gov/pubmed/19767775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.287
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