Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development

The challenges in recapitulating in vivo human T cell development in laboratory models have posed a barrier to understanding human thymopoiesis. Here we used single cell RNA-Seq to interrogate the rare CD34(+) progenitor and the more differentiated CD34(−) fractions in the human postnatal thymus. CD...

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Xehetasun bibliografikoak
Argitaratua izan da:Immunity
Egile Nagusiak: Le, J, Park, JE, Ha, VL, Luong, A, Branciamore, S, Rodin, AS, Gogoshin, G, Li, F, Loh, YH, Camacho, V, Patel, SB, Welner, RS, Parekh, C
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388724/
https://ncbi.nlm.nih.gov/pubmed/32553173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.05.010
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