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Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development
The challenges in recapitulating in vivo human T cell development in laboratory models have posed a barrier to understanding human thymopoiesis. Here we used single cell RNA-Seq to interrogate the rare CD34(+) progenitor and the more differentiated CD34(−) fractions in the human postnatal thymus. CD...
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| Pubblicato in: | Immunity |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7388724/ https://ncbi.nlm.nih.gov/pubmed/32553173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.05.010 |
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