The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation

BACKGROUND: Aberrant activation of the Hedgehog (Hh) signaling pathway is frequently observed in hepatocellular carcinoma (HCC), nevertheless, the precise molecular mechanism remains unclear. Forkhead box M1 (FOXM1), a target of the Hh pathway, is a key oncofetal transcription factor and a master ce...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Wang, Yiting, Wang, Hailong, Yan, Zhengwei, Li, Guohua, Hu, Guohui, Zhang, Hong, Huang, Dengliang, Wang, Yao, Zhang, Xiang, Yan, Yehong, Lu, Quqin, Cheng, Minzhang, Luo, Shiwen
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388463/
https://ncbi.nlm.nih.gov/pubmed/32723329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00628-4
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