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Multivalent antigen arrays exhibit high avidity binding and modulation of B cell receptor-mediated signaling to drive efficacy against experimental autoimmune encephalomyelitis
A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgA(PLP:LABL)), consisting of a hyaluronic acid (HA) linear polymer backbone co-grafted w...
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| Publicado no: | Biomacromolecules |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7388272/ https://ncbi.nlm.nih.gov/pubmed/28474886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b00335 |
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