Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways

Evidence suggests interplay among the three major risk factors for Alzheimer’s disease (AD): age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of brain transcriptomes and blood metabolomes from human apoE2, apoE3 and apoE4-targeted replacement mice across young, middl...

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Udgivet i:Neuron
Main Authors: Zhao, Na, Ren, Yingxue, Yamazaki, Yu, Qiao, Wenhui, Li, Fuyao, Felton, Lindsey M., Mahmoudiandehkordi, Siamak, Kueider-Paisley, Alexandra, Sonoustoun, Berkiye, Arnold, Matthias, Shue, Francis, Zheng, Jiaying, Attrebi, Olivia N., Martens, Yuka A., Li, Zonghua, Bastea, Ligia, Meneses, Axel D., Chen, Kai, Thompson, J. Will, John-Williams, Lisa St., Tachibana, Masaya, Aikawa, Tomonori, Oue, Hiroshi, Job, Lucy, Yamazaki, Akari, Liu, Chia-Chen, Storz, Peter, Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Kaddurah-Daouk, Rima, Bu, Guojun
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388065/
https://ncbi.nlm.nih.gov/pubmed/32199103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.02.034
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