Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes and identify genes in the alternative bile acid synthesis pathway to be expressed...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Baloni, Priyanka, Funk, Cory C., Yan, Jingwen, Yurkovich, James T., Kueider-Paisley, Alexandra, Nho, Kwangsik, Heinken, Almut, Jia, Wei, Mahmoudiandehkordi, Siamak, Louie, Gregory, Saykin, Andrew J., Arnold, Matthias, Kastenmüller, Gabi, Griffiths, William J., Thiele, Ines, Kaddurah-Daouk, Rima, Price, Nathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691449/
https://ncbi.nlm.nih.gov/pubmed/33294859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100138
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