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Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel

In proteins with multiple functions, such as macrophage migration inhibitory factor (MIF), the study of its intramolecular dynamic network can offer a unique opportunity to understand how a single protein is able to carry out several nonoverlapping functions. A dynamic mechanism that controls the MI...

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Библиографические подробности
Опубликовано в: :Cell Chem Biol
Главные авторы: Pantouris, Georgios, Khurana, Leepakshi, Ma, Anthony, Skeens, Erin, Reiss, Krystle, Batista, Victor S., Lisi, George P., Lolis, Elias J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388010/
https://ncbi.nlm.nih.gov/pubmed/32433911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.001
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