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Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel

In proteins with multiple functions, such as macrophage migration inhibitory factor (MIF), the study of its intramolecular dynamic network can offer a unique opportunity to understand how a single protein is able to carry out several nonoverlapping functions. A dynamic mechanism that controls the MI...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Pantouris, Georgios, Khurana, Leepakshi, Ma, Anthony, Skeens, Erin, Reiss, Krystle, Batista, Victor S., Lisi, George P., Lolis, Elias J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388010/
https://ncbi.nlm.nih.gov/pubmed/32433911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.001
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