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Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel

In proteins with multiple functions, such as macrophage migration inhibitory factor (MIF), the study of its intramolecular dynamic network can offer a unique opportunity to understand how a single protein is able to carry out several nonoverlapping functions. A dynamic mechanism that controls the MI...

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Publicado en:Cell Chem Biol
Autores principales: Pantouris, Georgios, Khurana, Leepakshi, Ma, Anthony, Skeens, Erin, Reiss, Krystle, Batista, Victor S., Lisi, George P., Lolis, Elias J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388010/
https://ncbi.nlm.nih.gov/pubmed/32433911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.001
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