Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia

Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use o...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Tift, Michael S., Alves de Souza, Rodrigo W., Weber, Janick, Heinrich, Erica C., Villafuerte, Francisco C., Malhotra, Atul, Otterbein, Leo E., Simonson, Tatum S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387684/
https://ncbi.nlm.nih.gov/pubmed/32792988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00886
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