Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

Dipeptidyl peptidase-4 (DPP4) modulates inflammation by enzymatic cleavage of immunoregulatory peptides and through its soluble form (sDPP4) that directly engages immune cells. Here we examine whether reduction of DPP4 activity alters inflammation. Prolonged DPP4 inhibition increases plasma levels o...

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Publicado no:Nat Commun
Main Authors: Baggio, Laurie L., Varin, Elodie M., Koehler, Jacqueline A., Cao, Xiemin, Lokhnygina, Yuliya, Stevens, Susanna R., Holman, Rury R., Drucker, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387453/
https://ncbi.nlm.nih.gov/pubmed/32724076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17556-z
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