Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

Dipeptidyl peptidase-4 (DPP4) modulates inflammation by enzymatic cleavage of immunoregulatory peptides and through its soluble form (sDPP4) that directly engages immune cells. Here we examine whether reduction of DPP4 activity alters inflammation. Prolonged DPP4 inhibition increases plasma levels o...

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Vydáno v:Nat Commun
Hlavní autoři: Baggio, Laurie L., Varin, Elodie M., Koehler, Jacqueline A., Cao, Xiemin, Lokhnygina, Yuliya, Stevens, Susanna R., Holman, Rury R., Drucker, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387453/
https://ncbi.nlm.nih.gov/pubmed/32724076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17556-z
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