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Differential Effects of PPAR-γ Activation versus Chemical or Genetic Reduction of DPP-4 Activity on Bone Quality in Mice

Patients with type 2 diabetes mellitus have an increased risk of fracture that can be further exacerbated by thiazolidinediones. A new class of antidiabetic agents control glucose through reduction of dipeptidyl peptidase-4 (DPP-4) activity; however the importance of DPP-4 for the control of bone qu...

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Autors principals: Kyle, Kimberly A., Willett, Thomas L., Baggio, Laurie L., Drucker, Daniel J., Grynpas, Marc D.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084690/
https://ncbi.nlm.nih.gov/pubmed/21177828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-1098
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