Distinct conformational states underlie pausing during initiation of HIV-1 reverse transcription

A hallmark of the initiation step of HIV-1 reverse transcription, in which viral RNA genome is converted into double-stranded DNA, is that it is slow and non-processive. Biochemical studies have identified specific sites along the viral RNA genomic template in which reverse transcriptase (RT) stalls...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Larsen, Kevin P., Choi, Junhong, Jackson, Lynnette N., Kappel, Kalli, Zhang, Jingji, Ha, Betty, Chen, Dong-Hua, Puglisi, Elisabetta Viani
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387199/
https://ncbi.nlm.nih.gov/pubmed/32512005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.06.003
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