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High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs
Reverse transcription of the HIV-1 viral RNA genome (vRNA) is an integral step in virus replication. Upon viral entry, HIV-1 reverse transcriptase (RT) initiates from a host tRNA(Lys)(3) primer bound to the vRNA genome and is the target of key antivirals, such as non-nucleoside reverse transcriptase...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8096811/ https://ncbi.nlm.nih.gov/pubmed/33947853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22628-9 |
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