High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs

Reverse transcription of the HIV-1 viral RNA genome (vRNA) is an integral step in virus replication. Upon viral entry, HIV-1 reverse transcriptase (RT) initiates from a host tRNA(Lys)(3) primer bound to the vRNA genome and is the target of key antivirals, such as non-nucleoside reverse transcriptase...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ha, Betty, Larsen, Kevin P., Zhang, Jingji, Fu, Ziao, Montabana, Elizabeth, Jackson, Lynnette N., Chen, Dong-Hua, Puglisi, Elisabetta Viani
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096811/
https://ncbi.nlm.nih.gov/pubmed/33947853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22628-9
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