Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nassar, Zeyad D, Mah, Chui Yan, Dehairs, Jonas, Burvenich, Ingrid JG, Irani, Swati, Centenera, Margaret M, Helm, Madison, Shrestha, Raj K, Moldovan, Max, Don, Anthony S, Holst, Jeff, Scott, Andrew M, Horvath, Lisa G, Lynn, David J, Selth, Luke A, Hoy, Andrew J, Swinnen, Johannes V, Butler, Lisa M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386908/
https://ncbi.nlm.nih.gov/pubmed/32686647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54166
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