Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Nassar, Zeyad D, Mah, Chui Yan, Dehairs, Jonas, Burvenich, Ingrid JG, Irani, Swati, Centenera, Margaret M, Helm, Madison, Shrestha, Raj K, Moldovan, Max, Don, Anthony S, Holst, Jeff, Scott, Andrew M, Horvath, Lisa G, Lynn, David J, Selth, Luke A, Hoy, Andrew J, Swinnen, Johannes V, Butler, Lisa M
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386908/
https://ncbi.nlm.nih.gov/pubmed/32686647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54166
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