Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange and is affected by disorders including interstitial lung disease, cancer, and SARS-CoV-2-associated COVID-19 pneumonia. Investigations of these localized pathologies have been hindered by a lack of 3D in vitro hum...

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Pubblicato in:bioRxiv
Autori principali: Salahudeen, Ameen A., Choi, Shannon S., Rustagi, Arjun, Zhu, Junjie, de la O, Sean M., Flynn, Ryan A, Margalef-Català, Mar, Santos, António J.M., Ju, Jihang, Batish, Arpit, van Unen, Vincent, Usui, Tatsuya, Zheng, Grace X.Y., Edwards, Caitlin E., Wagar, Lisa E, Luca, Vincent, Anchang, Benedict, Nagendran, Monica, Nguyen, Khanh, Hart, Daniel J., Terry, Jessica M., Belgrader, Phillip, Ziraldo, Solongo B., Mikkelsen, Tarjei S., Harbury, Pehr B., Glenn, Jeffrey S., Garcia, K. Christopher, Davis, Mark M., Baric, Ralph S., Sabatti, Chiara, Amieva, Manuel R., Blish, Catherine A., Desai, Tushar J., Kuo, Calvin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386503/
https://ncbi.nlm.nih.gov/pubmed/32743583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.27.212076
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