Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial lung disease, cancer and coronavirus disease 2019 (COVID-19) pneumonia...

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Published in:Nature
Main Authors: Salahudeen, Ameen A., Choi, Shannon S., Rustagi, Arjun, Zhu, Junjie, van Unen, Vincent, de la O, Sean M., Flynn, Ryan A., Margalef-Català, Mar, Santos, António J. M., Ju, Jihang, Batish, Arpit, Usui, Tatsuya, Zheng, Grace X. Y., Edwards, Caitlin E., Wagar, Lisa E., Luca, Vincent, Anchang, Benedict, Nagendran, Monica, Nguyen, Khanh, Hart, Daniel J., Terry, Jessica M., Belgrader, Phillip, Ziraldo, Solongo B., Mikkelsen, Tarjei S., Harbury, Pehr B., Glenn, Jeffrey S., Garcia, K. Christopher, Davis, Mark M., Baric, Ralph S., Sabatti, Chiara, Amieva, Manuel R., Blish, Catherine A., Desai, Tushar J., Kuo, Calvin J.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8003326/
https://ncbi.nlm.nih.gov/pubmed/33238290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-3014-1
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