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HIV-1 Integrase and Virus and Cell DNAs: Complex Formation and Perturbation by Inhibitors of Integration

HIV-1 integrase (IN) catalyzes integration of viral DNA into cell DNA through 30-processing of viral DNA and strand transfer reactions. To learn on binding of IN to DNAs and IN inhibition we applied spectroscopy (circular dichroism, fluorescence) in a simplified model consisting in a peptide analogu...

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Detalhes bibliográficos
Publicado no:Neurochem Res
Main Authors: Hobaika, Z., Zargarian, L., Maroun, R. G., Mauffret, O., Burke, T. R., Fermandjian, S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386435/
https://ncbi.nlm.nih.gov/pubmed/19937113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-009-0098-2
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