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Blockade of the lysophosphatidylserine lipase ABHD12 potentiates ferroptosis in cancer cells

Ferroptosis is a type of cell death caused by the pathogenic accumulation of lipid hydroperoxides. Pharmacological mechanisms to induce ferroptosis may provide a way to kill cancer cells that are resistant to other forms of cell death like apoptosis. Nonetheless, the proteins that regulate ferroptot...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Kathman, Stefan G., Boshart, Julia, Jing, Hui, Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386317/
https://ncbi.nlm.nih.gov/pubmed/32195565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00086
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