Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo

ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12(−/−) mice display PHARC-like phenotypes, including hearing loss, along with elevated brain lyso-PS and features of stimul...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Ogasawara, Daisuke, Aki-Ichu, Taka, Vartabedian, Vincent, Benthuysen, Jacqueline, Jing, Hui, Reed, Alex, Ulanovskaya, Olesya, Hulce, Jonathan J., Roberts, Amanda, Brown, Steven, Rosen, Hugh, Teijaro, John R., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263940/
https://ncbi.nlm.nih.gov/pubmed/30420694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0155-8
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