ABHD12 and LPCAT3 interplay regulates a lyso-phosphatidylserine-C20:4 phosphatidylserine lipid network implicated in neurological disease

PHARC (polyneuropathy, hearing loss, cerebellar ataxia, retinitis pigmentosa, early-onset cataracts) is a human neurological disorder caused by deleterious mutations in the ABHD12 gene, which encodes an integral membrane lyso-phosphatidylserine (lyso-PS) lipase. Pharmacological or genetic disruption...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Ichu, Taka-Aki, Reed, Alex, Ogasawara, Daisuke, Ulanovskaya, Olesya, Roberts, Amanda, Aguirre, Carlos A., Bar-Peled, Liron, Gao, Jie, Germain, Jason, Barbas, Sabrina, Masuda, Kim, Conti, Bruno, Tontonoz, Peter, Cravatt, Benjamin F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394188/
https://ncbi.nlm.nih.gov/pubmed/32364701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00292
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