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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunoge...

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Publié dans:NPJ Vaccines
Auteurs principaux: Graham, Simon P., McLean, Rebecca K., Spencer, Alexandra J., Belij-Rammerstorfer, Sandra, Wright, Daniel, Ulaszewska, Marta, Edwards, Jane C., Hayes, Jack W. P., Martini, Veronica, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Waters, Ryan, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Gilbride, Ciaran, Pulido, David, Moffat, Katy, Sharpe, Hannah, Allen, Elizabeth, Mioulet, Valerie, Chiu, Chris, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Huo, Jiandong, Owens, Raymond J., Carroll, Miles, Hammond, John A., Tchilian, Elma, Bailey, Dalan, Charleston, Bryan, Gilbert, Sarah C., Tuthill, Tobias J., Lambe, Teresa
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385486/
https://ncbi.nlm.nih.gov/pubmed/32793398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-00221-3
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