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Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN‐amplified neuroblastoma cells

MYCN gene amplification is consistently associated with poor prognosis in patients with neuroblastoma, a pediatric tumor arising from the sympathetic nervous system. Conventional anticancer drugs, such as alkylating agents and platinum compounds, have been used for the treatment of high‐risk patient...

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Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Yamashita, Ken, Kiyonari, Shinichi, Tsubota, Shoma, Kishida, Satoshi, Sakai, Ryuichi, Kadomatsu, Kenji
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385364/
https://ncbi.nlm.nih.gov/pubmed/32415892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14485
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