Molecular engineering of safe and efficacious oral basal insulin

Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharmacological properties of these insulin analogues....

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Publicado no:Nat Commun
Main Authors: Hubálek, Frantisek, Refsgaard, Hanne H. F., Gram-Nielsen, Sanne, Madsen, Peter, Nishimura, Erica, Münzel, Martin, Brand, Christian Lehn, Stidsen, Carsten Enggaard, Claussen, Christian Hove, Wulff, Erik Max, Pridal, Lone, Ribel, Ulla, Kildegaard, Jonas, Porsgaard, Trine, Johansson, Eva, Steensgaard, Dorte Bjerre, Hovgaard, Lars, Glendorf, Tine, Hansen, Bo Falck, Jensen, Maja Kirkegaard, Nielsen, Peter Kresten, Ludvigsen, Svend, Rugh, Susanne, Garibay, Patrick W., Moore, Mary Courtney, Cherrington, Alan D., Kjeldsen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385171/
https://ncbi.nlm.nih.gov/pubmed/32719315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17487-9
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