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Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs

Glycinergic synapses play a central role in motor control and pain processing in the central nervous system. Glycine receptors (GlyRs) are key players in mediating fast inhibitory neurotransmission at these synapses. While previous high-resolution structures have provided insights into the molecular...

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Vydáno v:Nat Commun
Hlavní autoři: Kumar, Arvind, Basak, Sandip, Rao, Shanlin, Gicheru, Yvonne, Mayer, Megan L., Sansom, Mark S. P., Chakrapani, Sudha
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385131/
https://ncbi.nlm.nih.gov/pubmed/32719334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17364-5
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