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SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages

Human immunodeficiency type 1 (HIV)-infected macrophages (HIV-Mφ) are a reservoir for latent HIV infection and a barrier to HIV eradication. In contrast to CD4+ T cells, HIV-Mφ are resistant to the cytopathic effects of acute HIV infection and have increased expression of cell survival factors, incl...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Campbell, Grant R., To, Rachel K., Zhang, Gang, Spector, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385130/
https://ncbi.nlm.nih.gov/pubmed/32719312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02761-x
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