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SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected resting memory CD4+ T cells

Long-lived resting memory CD4+ T cells (T(CM)) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-T(CM) are maintained by aberrant expression of cell survival factors, including XIAP, BIRC2/cIAP1 and beclin-1. DIABLO/SMAC mimetics are therapeutic agents that compromise ce...

詳細記述

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書誌詳細
出版年:Cell Host Microbe
主要な著者: Campbell, Grant R., Bruckman, Rachel S., Chu, Yen-Lin, Trout, Rodney N., Spector, Stephen A.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250054/
https://ncbi.nlm.nih.gov/pubmed/30344003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.09.007
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