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SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected resting memory CD4+ T cells
Long-lived resting memory CD4+ T cells (T(CM)) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-T(CM) are maintained by aberrant expression of cell survival factors, including XIAP, BIRC2/cIAP1 and beclin-1. DIABLO/SMAC mimetics are therapeutic agents that compromise ce...
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| Publicat a: | Cell Host Microbe |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6250054/ https://ncbi.nlm.nih.gov/pubmed/30344003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.09.007 |
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