Ablation of reactive astrocytes exacerbates disease pathology in a model of Alzheimer's disease

The role of astrocytes in the progression of Alzheimer's disease (AD) remains poorly understood. We assessed the consequences of ablating astrocytic proliferation in 9 months old double transgenic APP23/GFAP‐TK mice. Treatment of these mice with the antiviral agent ganciclovir conditionally abl...

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Vydáno v:Glia
Hlavní autoři: Katsouri, Loukia, Birch, Amy M., Renziehausen, Alexander W. J., Zach, Carolin, Aman, Yahyah, Steeds, Hannah, Bonsu, Angela, Palmer, Emily O. C., Mirzaei, Nazanin, Ries, Miriam, Sastre, Magdalena
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383629/
https://ncbi.nlm.nih.gov/pubmed/31799735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23759
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