Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease

BACKGROUND: Astrocytes provide a vital support to neurons in normal and pathological conditions. In Alzheimer’s disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. However, their role and potential mechanisms whereby they affect neuroinfl...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Davis, Nicola, Mota, Bibiana C., Stead, Larissa, Palmer, Emily O. C., Lombardero, Laura, Rodríguez-Puertas, Rafael, de Paola, Vincenzo, Barnes, Samuel J., Sastre, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7972219/
https://ncbi.nlm.nih.gov/pubmed/33731156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02117-y
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