A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program

Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic development that coincides with extensive epigenetic reprogramming. Complex manipulation techniques and maternal stores of proteins preclude large-scale functional screens for ZGA regulators within early embryos. Here...

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Pubblicato in:Cell Syst
Autori principali: Alda-Catalinas, Celia, Bredikhin, Danila, Hernando-Herraez, Irene, Santos, Fátima, Kubinyecz, Oana, Eckersley-Maslin, Mélanie A., Stegle, Oliver, Reik, Wolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383230/
https://ncbi.nlm.nih.gov/pubmed/32634384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.06.004
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