A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program

Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic development that coincides with extensive epigenetic reprogramming. Complex manipulation techniques and maternal stores of proteins preclude large-scale functional screens for ZGA regulators within early embryos. Here...

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Bibliographic Details
Published in:Cell Syst
Main Authors: Alda-Catalinas, Celia, Bredikhin, Danila, Hernando-Herraez, Irene, Santos, Fátima, Kubinyecz, Oana, Eckersley-Maslin, Mélanie A., Stegle, Oliver, Reik, Wolf
Format: Artigo
Language:Inglês
Published: Cell Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383230/
https://ncbi.nlm.nih.gov/pubmed/32634384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.06.004
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