Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

BACKGROUND: Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role in intercellular communication via transfer of genetic material. However, the miRNAs in exosome...

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Dettagli Bibliografici
Pubblicato in:J Nanobiotechnology
Autori principali: Jiang, Dongdong, Gong, Fangyi, Ge, Xuhui, Lv, Chengtang, Huang, Chenyu, Feng, Shuang, Zhou, Zheng, Rong, Yuluo, Wang, Jiaxing, Ji, Chengyue, Chen, Jian, Zhao, Wene, Fan, Jin, Liu, Wei, Cai, Weihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382861/
https://ncbi.nlm.nih.gov/pubmed/32711535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-020-00665-8
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