Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

BACKGROUND: Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role in intercellular communication via transfer of genetic material. However, the miRNAs in exosome...

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Vydáno v:J Nanobiotechnology
Hlavní autoři: Jiang, Dongdong, Gong, Fangyi, Ge, Xuhui, Lv, Chengtang, Huang, Chenyu, Feng, Shuang, Zhou, Zheng, Rong, Yuluo, Wang, Jiaxing, Ji, Chengyue, Chen, Jian, Zhao, Wene, Fan, Jin, Liu, Wei, Cai, Weihua
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382861/
https://ncbi.nlm.nih.gov/pubmed/32711535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-020-00665-8
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