Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating...

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Vydáno v:Nat Commun
Hlavní autoři: Lara, Julia, Diacovich, Lautaro, Trajtenberg, Felipe, Larrieux, Nicole, Malchiodi, Emilio L., Fernández, Marisa M., Gago, Gabriela, Gramajo, Hugo, Buschiazzo, Alejandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382501/
https://ncbi.nlm.nih.gov/pubmed/32710080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17504-x
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