Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase

A ring-shaped helicase unwinds DNA during chromosome replication in all organisms. Replicative helicases generally unwind duplex DNA an order of magnitude slower compared to their in vivo replication fork rates. However, the origin of slow DNA unwinding rates by replicative helicases and the mechani...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kose, Hazal B., Xie, Sherry, Cameron, George, Strycharska, Melania S., Yardimci, Hasan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382467/
https://ncbi.nlm.nih.gov/pubmed/32709841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17443-7
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