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Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5, and 11 is an essential step in initiating pyroptosis following inflammasome activation. Previous work has identified cleavage site signatures in substrates such as GSDMD, but it is unclear if these are the sole det...
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| Published in: | Immunity |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7382298/ https://ncbi.nlm.nih.gov/pubmed/32553275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.06.007 |
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