Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage

The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5, and 11 is an essential step in initiating pyroptosis following inflammasome activation. Previous work has identified cleavage site signatures in substrates such as GSDMD, but it is unclear if these are the sole det...

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Bibliographic Details
Published in:Immunity
Main Authors: Liu, Zhonghua, Wang, Chuanping, Yang, Jie, Chen, Yinghua, Zhou, Bowen, Abbott, Derek W., Xiao, Tsan Sam
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382298/
https://ncbi.nlm.nih.gov/pubmed/32553275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.06.007
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