Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid-binding, and oligomerization

Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases trigger the oligomerization and lipid-binding by its N-terminal domain that assembles membrane pores, whereas its C-terminal...

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Publicado en:Immunity
Autores principales: Liu, Zhonghua, Wang, Chuanping, Yang, Jie, Zhou, Bowen, Yang, Rui, Ramachandran, Rajesh, Abbott, Derek W., Xiao, Tsan Sam
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640092/
https://ncbi.nlm.nih.gov/pubmed/31097341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.04.017
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