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Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid-binding, and oligomerization
Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases trigger the oligomerization and lipid-binding by its N-terminal domain that assembles membrane pores, whereas its C-terminal...
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| Pubblicato in: | Immunity |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640092/ https://ncbi.nlm.nih.gov/pubmed/31097341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.04.017 |
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