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Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition
Pyroptosis is an inflammatory form of programmed cell death that plays important roles in immune protection against infections and in inflammatory disorders. Gasdermin D (GSDMD) is an executor of pyroptosis upon cleavage by caspases-1/4/5/11 following canonical and noncanonical inflammasome activati...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5932255/ https://ncbi.nlm.nih.gov/pubmed/29576317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.03.002 |
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