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Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome
Wolfram syndrome is a rare multisystem disease characterized by childhood-onset diabetes mellitus and progressive neurodegeneration. Most cases are attributed to pathogenic variants in a single gene, Wolfram syndrome 1 (WFS1). There currently is no disease-modifying treatment for Wolfram syndrome, a...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7382278/ https://ncbi.nlm.nih.gov/pubmed/32632005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007136117 |
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