Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin

DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability. We screened a chemical library designed to target the human kinome for new activities that mediate gene silencing on DSB-flanking chromatin,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dong, Chao, West, Kirk L., Tan, Xin Yi, Li, Junshi, Ishibashi, Toyotaka, Yu, Cheng-han, Sy, Shirley M. H., Leung, Justin W. C., Huen, Michael S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382216/
https://ncbi.nlm.nih.gov/pubmed/32611815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002193117
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