Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation

Background: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), induced upon T cell activation but degraded quickly, has been targeted in the clinical therapy of advanced cancers and autoimmune diseases. However, whether inhibiting CTLA-4 degradation ameliorates transplant rejection rem...

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Publicado en:Theranostics
Autores principales: Cui, Jikai, Yu, Jizhang, Xu, Heng, Zou, Yanqiang, Zhang, Hao, Chen, Shanshan, Le, Sheng, Zhao, Jing, Jiang, Lang, Xia, Jiahong, Wu, Jie
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2020
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7381746/
https://ncbi.nlm.nih.gov/pubmed/32724457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.43507
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