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MEK or ERK inhibition effectively abrogates emergence of acquired osimertinib resistance in the treatment of EGFR-mutant lung cancers
BACKGROUND: The majority of non-small cell lung cancer (NSCLC) patients harboring activating EGFR mutations respond well to osimertinib (AZD9291), a third generation mutation-selective epidermal growth factor receptor (EGFR) inhibitor. The current study focuses on determining whether targeting MEK/E...
Shranjeno v:
| izdano v: | Cancer |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7381372/ https://ncbi.nlm.nih.gov/pubmed/32497272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.32996 |
| Oznake: |
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