Overcoming acquired resistance to AZD9291, a third generation EGFR inhibitor, through modulation of MEK/ERK-dependent Bim and Mcl-1 degradation

PURPOSE: The mechanisms accounting for anticancer activity of AZD9291 (osimertinib or TAGRISSO™), an approved third generation EGFR inhibitor, in EGFR-mutant non-small cell lung cancer (NSCLC) cells and particularly for the subsequent development of acquired resistance are unclear and thus are the f...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Shi, Puyu, Oh, You-Take, Deng, Liang, Zhang, Guojing, Qian, Guoqing, Zhang, Shuo, Ren, Hui, Wu, Grant, Legendre, Benjamin, Anderson, Emily, Ramalingam, Suresh S., Owonikoko, Taofeek K., Chen, Mingwei, Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668147/
https://ncbi.nlm.nih.gov/pubmed/28765329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1574
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