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Inhibition of ACK1 delays and overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib

OBJECTIVES: The emergence of acquired resistance to the third generation EGFR inhibitor, osimertinib (AZD9291 or TAGRISSO™), is an unavoidable huge clinical challenge. The involvement of ACK1, a non-receptor tyrosine kinase with an oncogenic function, in regulating cell response to osimertinib has n...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Lung Cancer
Main Authors: Gu, Jiajia, Qian, Luxi, Zhang, Guojing, Mahajan, Nupam P., Owonikoko, Taofeek K., Ramalingam, Suresh S., Sun, Shi-Yong
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722235/
https://ncbi.nlm.nih.gov/pubmed/33049499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2020.09.023
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