A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) - has the potential to improve the efficiency of gene targeting by CRISPR/Cas9. Here, we have developed a rapid and easy...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Zhang, Weina, Chen, Yu, Yang, Jiaqing, Zhang, Jing, Yu, Jiayu, Wang, Mengting, Zhao, Xiaodong, Wei, Ke, Wan, Xiaoping, Xu, Xiaojun, Jiang, Ying, Chen, Jiayu, Gao, Shaorong, Mao, Zhiyong
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380943/
https://ncbi.nlm.nih.gov/pubmed/32644042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56008
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