A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) - has the potential to improve the efficiency of gene targeting by CRISPR/Cas9. Here, we have developed a rapid and easy...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Zhang, Weina, Chen, Yu, Yang, Jiaqing, Zhang, Jing, Yu, Jiayu, Wang, Mengting, Zhao, Xiaodong, Wei, Ke, Wan, Xiaoping, Xu, Xiaojun, Jiang, Ying, Chen, Jiayu, Gao, Shaorong, Mao, Zhiyong
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380943/
https://ncbi.nlm.nih.gov/pubmed/32644042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56008
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы